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Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor, and it works by increasing blood flow to certain areas of the body, particularly the penis. Here's how Tadalafil works:
Relaxation of Blood Vessels: Tadalafil primarily acts by inhibiting the enzyme PDE5, which is responsible for breaking down cyclic guanosine monophosphate (cGMP). cGMP is a chemical messenger that helps relax smooth muscle tissues and dilate blood vessels.
Increased Nitric Oxide Production: When a man is sexually stimulated, the release of nitric oxide (NO) occurs in the erectile tissue of the penis. Nitric oxide then activates an enzyme called guanylate cyclase, leading to an increase in cGMP levels.
Smooth Muscle Relaxation: Elevated cGMP levels cause the smooth muscles in the penile arteries to relax. This relaxation allows an increased blood flow into the penis, leading to the engorgement and erection of the penis during sexual stimulation.